Pancreatitis Pancreatitis can either be acute or chronic. We will mainly talk about acute pancreatitis here. Acute pancreatitis Characteristics: enzymatic necrosis and inflammation of pancreas, increase in pancreatic enzymes in blood and urine Result: acute onset of epigastric pain (worse in supine position, radiates to back), cause and vomiting, abdominal distention due to fluid accumulation, pseudocyst (cyst with fibrous or granulation tissue), systemic organ shock, renal failure, intravascular coagulation, duodenal obstruction Cause: alcohol, gallstones, trauma Pathogenies: amylase, lipase and protease leak out of pancreatic acinus and pancreatic duct, causing a steep rise in amylase and smaller rise in lipase blood levels. Lipase causes fat necrosis and protease causes blood vessel destruction and haemorrhage. Diagnosis: sharp increase amylase, followed by smaller, slower increase in lipase levels Consequences of chronic pancreatitis Pancreatic pseudocys...
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